The Fatima Prayer Cell Program is a global apostolate response to Our Lady’s call for prayer, penance and sacrifice. Cells consist of groups of two or more people who pray together on a regular basis uniting themselves with prayer cell members throughout the world through the inclusion of the World Apostolate of Fatima Universal Prayer Cell Intentions in their prayers.

Prayer cell members follow the Fatima Prayer Cell Program booklet, which includes a "flip" book, Lucia Speaks, based on Sister Lucia’s memoir of the apparitions at Fatima.